Introduction: The aim of this study was to evaluate the outcome-including long term effects of Non-invasive Domiciliary Ventilation (NIDV) in our elderly patients and to assess what factors were associated with their survival.
Material and methods: Prospective study that included all patients of our Service who started NIDV at 75 years of older (January 2002 - April 2015). Analysis of survival was undertaken using Kaplan-Meier method and Cox regression.
Results: 82 patients were included (72% women, mean age: 79.9 ± 3,7 years). 67% had more than three comorbidities. The most frequent causal diseases were: Obesity hypoventilation syndrome (65,9 %) and restrictive diseases (17,1 %). Significants improvements were obtained in diurnal blood gases at discharge (PaO2, PaCO2, ph) and in the follow-up (PaCO2) as well as a significant decrease in the number of hospital admissions. The mean compliance was 8.7 ± 3.2 h/day although tolerance at home was considered to be deficient in 50 %. In the end of the follow-up (median 15 months; range 0 - 135) the mortality was 70.7 %. The estimated survival at 1º year, 2 º year and 3 º year was 63 %, 56 % and 44 %, respectively. Survival was independently associated with: good compliance, restrictive disease, lower EPAP level and lower dyspnea level (mMRC) in the follow-up.
Conclusions: The results of the NIDV in elderly patients are satisfactory improving arterial blood gases, hospital readmissions and achieving long survival. Survival was better in “good compliance” patients, in restrictive diseases and with lower dyspnea level at follow up.